What is 2-Iminothiolane CAS 4781-83-3? 2-Iminothiolane is a white to grayish-white powder and a thiolating reagent of primary amines. When the pH is between 7 and 10, the amidine bond reacts to form free thiol groups. 2-Iminothiolane is used for the preparation of disulfide and/or sulfide bond conjugates. Specification ITEM STANDARD Appearance White crystals Purity ≥95% Water ≤1% Applications 1. Biomolecular thiolation modification: As a thiolation reagent, 2-iminothiane hydrochloride can specifically react with the primary amino groups on biomolecules such as proteins, peptides, and polysaccharides under pH conditions of 7-9, introducing thiol groups. This process not only provides new active sites for biomolecules but also retains the charge properties of the original amino groups, which is conducive to subsequent functional modifications. 2. Biomolecular coupling and crosslinking: The introduced thiol groups can be used to prepare conjugates linked by disulfide or thioether bonds, achieving coupling between biomolecules. For instance, in proteomics research, 2-Iminothiolane can be used for peptide labeling and the study of biomolecular interactions, as well as for RNA-protein cross-linking, which is conducive to in-depth exploration of the structural and functional relationship of biomolecules. Features 1. Purity ≥ 95%, exceeding industry standard; 2. Moisture content ≤1%, the insulation performance great; 3. Excellent thermal stability 4. In stock Packaging 25kg/drum, 25kg/bag
